Protective effect of propofol on free radical induced cortex mitochondria injury in rats

Abstract

Abstract: AIM: To evaluate the protective effects of propofol on oxidative injury of rat cortex mitochondria. METHODS: Lipid peroxidation was induced by ascorbic acid-Fe²⁺, the swelling of mitochondria and the decrease of membrane fluidity were induced by ascorbic acid-Fe²⁺ system.The fluidity of mitochondral membrane, content of malondialdehyde (MDA) in mitochondria and the swelling of mitochondria were measured. RESULTS: The swelling of mitochondria and the decrease of membrane fluidity induced by ascorbic acid-Fe²⁺ system were alleviated by propofol(P<0.05).30 μmol/L propofol could protect mitochondria from ascorbic acid-Fe²⁺ induced lipid peroxidation. CONCLUSION: Propofol can protect mitochondria from oxidative injury induced by ascorbic acid-Fe²⁺.

Key words: propofol, mitochondria membrane, membrane fluidity, oxygen free radical, lipid peroxidation

CLC Number:

R965.2

JIA Dong-lin, CHU Xiao-yu, ZHANG Li-ping. Protective effect of propofol on free radical induced cortex mitochondria injury in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(7): 763-766.

References

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