Diphasic action of nitric oxide in doxorubicin-induced cardiotoxicity

Abstract

Abstract: Anthracycline doxorubicin is a efficient antitumor drug, which be applied in treatment of hematology diseases and various kinds solid tumor.Doxorubicin induces multiplicitas biochemistry passage cell damage and lead to severe dose-dependent cardiotoxicity.So its application and therapeutic index are limited and affected.nitric oxide is an important biology messenger molecule.Its importment action in doxorubicininduced cardiotoxicity receives universal concern.This article summarizes the development of nitric oxide in doxorubin-induced cardiotoxicity by referring to recent domestic and overseas relevant referrences.

Key words: nitric oxide, nitric oxide synthase, doxorubicin, cardiotoxicity

CLC Number:

R966

XIN Yan-fei, ZHANG Li-li, XUAN Yao-xian. Diphasic action of nitric oxide in doxorubicin-induced cardiotoxicity[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(1): 117-120.

References

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