Abstract: AIM: To investigate the renoprotective effect of benazepril and pentifylline on adriamycin nephropathy rats.METHODS: A total 42 rats were randomly assigned to control group, model group, benazepril treatment group, pentifylline treatment group and combined treatment group.At the 8th week after operation, changes of the 24 hours urinary protein excretion, renal function, TP and Alb were also examined. Immunohistochemistry was performed to investigate renal pathological changes and the expression of MCP-1 and TGF-β₁.RESULTS: Combined treatment group could efficiently lowe the blood pressure [ PTX group (134±6) mm Hg, ACEI group(130±5) mm Hg, combined treatment group(126±5) mm Hg, control group(141±5) mm Hg] and the contents of proteinuria in treatment groups were decreased, the effect in ACEI group surpassed that in PTX group, but had no significance.The proteinuria in combined group was lowered than in single treatment group (P<0.01). Combined treatment group could efficiently decreased the expression of MCP-1 and TGF-β₁.CONCLUSION: Benazepril and pentifylline may play a protective role by depressing renal inflammation, interstitial fibrosis and lowering proteinuria.The effect of combination of benazepril and pentifylline is better than that of either.

Key words: adriamycin, nephronia, benazepril, pentifylline, combination, macrophage chemoattractant protein 1, transforming growth factor-β₁