Abstract: AIM: To choose the best formulation of marzulene-S grranuls oral membrane and to evaluate the clinical effects.METHODS: Orthogonal method was used for studying.Take the appearance, viscidity and dissolubility of the oral membrane as the indexes of scoring 108 cases of patients were chosen and divided into two groups randomly.58 case were treated with marzulene-S grranuls oral membrane and 50 cases were treated with gargarisma chlorhexidine as the control group.RESULTS: The best prescription is sodium carboxymethyl cellulose 4 %, polyvinyl alcohol1750 1 %and polyvinyl alcohol17-88 3 %.CONCLUSION: The design of the formulation is reasonable and the clinical effect was satisfactory.

Key words: marzulene-S, oral membrane, orthogonal method, clinical effect