Abstract: AIM: To investigate the effect of combined medication on treating hypertension and explore its role in left ventricular remodeling in renal vascular hypertension rats (two kidney one clip hypertensive rats) . METHODS: Forty-three SD rats were randomly di-vided into 4 groups:sham group (Group A, n =10) , hypertension group (Group B, n =11) , β-B +ACEI group (Group C, n =11 bisoprolol 5 mg°kg^-1 °d^-1 and benazepril 5 mg°kg^-1 °d^-1) , ACEI +CCB group (Group D, n =11 benazepril 5 mg°kg^-1 °d^-1 and am-lodipine 10 mg°kg^-1 °d^-1) .The rats were fed for 20 weeks, blood pressure and echocardiography of rats were monitored every 2 weeks.After 20 weeks, (rats were sacrificed and the blood and hearts were collect-ed, then the concentrationsof collagen Ⅲ, collagen Ⅳ and ANF were detected by immunohistochemistry .RESULTS: Compared with Group B, the blood pressure, the concentrations of collagen Ⅲ, collagen Ⅳ and ANF in medication groups were significantly reduced. Compared with Group A, the ANF was significantly in-creased in Group B, but the ANF was not significantly increased in medication groups(P<0.05). CONCLUSION: The combined effect of benazepril and amlodipine is better than bisoprolol and benazepril in reducing blood pressure and preventing target organ .

Key words: hypertension, collagen, atrial natriuretic factor, drug