Association of aldose reductase and its genetic polymorphisms with diabetic chronic complications

Abstract

Abstract: Diabetic chronic complications (DCC) are severely harmful to the health of human, and are major causes leading to death and deformity from diabetes.Aldose reductase (AR), a rate limiting enzyme in polyol metabolic pathway, has implicated in the pathogenesis and development of DCC.The polymorphisms in AR gene are proved to be ethnic different.These polymorphisms are related to DCC susceptibility.The investigation on the polymorphisms may be helpful to prevention and therapy of DCC.

Key words: aldose reductase, diabetic chronic complication(DCC), polymorphism

CLC Number:

R587.1

CHENG Huan-lian, OUYANG Dong-sheng. Association of aldose reductase and its genetic polymorphisms with diabetic chronic complications[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(2): 225-229.

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