Study progress on dose problem and pharmacokinetics of commonly used special antidote

Abstract

Abstract: To investigate the problems about dosage and pharmacokinetics of special antidotes in applications.Collected and analyzed the references about clinical applications, dosage correlative adverse reactions, pharmacokinetics and assaying methods of special antidotes in the last 30 years.Though special antidotes have significant effects in the clinical treatment of poisoning, theirs secondary damages and adverse reactions caused by inadequacy dose or overdose are also more prominent.The problems about the dosage of special antidotes in the clinical application are still the key to successful deintoxication.To handle the dosage accurately in clinical use, and to study their pharmacokinetics is necessary.

Key words: special antidote, dosage, pharmacokinetics

CLC Number:

R969

SONG Ya-juan, LIU Yang, DING Guo-hua. Study progress on dose problem and pharmacokinetics of commonly used special antidote[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(2): 220-224.

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