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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (8): 873-877.

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Effect of naftopidil'ramification-BWYJ on benign prostatic hyperplasia in mice and rats

YU Shuang, YU Li-mei1, YUAN Mu2, YU Hong3, WU Qin1, SHI Jin-shan1   

  1. Department of Pharmacology , Basic Medical College, ZhengzhouUniversity , Zhengzhou 450052 , Henan , China;
    1Department of Pharmacology , Zunyi Medical College , Zunyi 563003 , Guizhou, China;
    2theKey Laboratory of Chemistry for Natural products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002 , Guizhou, China;
    3Medical Department of Uropoiesis, Affiliated Hospital of Zunyi Medical College , Zunyi 563003 , Guizhou, China
  • Received:2006-02-07 Revised:2006-04-09 Online:2006-08-26 Published:2020-11-05

Abstract: AIM: To observe the effect of naftopidilderivant BWYJ on benign prostatic hyperplasia (BPH) induced by testosterone propionate in castrated rats and uncastrated mice.METHODS: Castrated rats and uncastrated mice were injected subcutaneously testosterone propionate to induce BPH.The effect of BWYJ on mice with BPH was obtained by the prostatic wet weight and wet weight index.As well morphological changes of prostate were observed through light microscope and electron microscope,and were semi-quantified by image analysis system.The apoptotsis of prostatic cells in rat was detected by TUNEL assay.RESULTS: BWYJ decreased the prostate wet weight index (P<0.05).BWYJ inhibited histomorphological changes of BPH induced by testosterone propionate in uncastrated mice.Few apoptosis cell was detected by TUNEL assay in BWYJ-treated groups compared with model grouP(P>0.05).CONCLUSION: BWYJ inhibits BPH induced by testosterone propionate in KM mice and SD rat.

Key words: naftopidil'ramification, BWYJ, benign prostatic hyperplasia, histopathology, electron microscope, apoptosis

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