Effects of propafenone on interventricular repolarization heterogeneity in ischemic myocardium in rabbits

Abstract

Abstract: AIM: To observe the effects of propafenone on interventricular repolarization heterogeneity between two ventricles in isolated ischemic myocardium in rabbits, and with the action potential duration (APD), to approach the electropharmacologic mechanism of arrhythmogenic of propafenone in patients with myocardium ischemia in clinical practice.METHODS: To observe the effect of propafenone, we gave various concentration gradient (1, 6, 10 μmol/L) on the APD of endocardium myocytes in ischemic state with whole cell patch-clamp through alterring frequency of stimulation.RESULTS: Propafenone could enlarge the interventricular repolarization dispersion when the concentration of propafenone from 1 to 10 μmol/L.The endocardium APD characterized dependence on slow frequency when given various gradients of propafenone (P <0.05) and this characteristic was independent on the gradients of propafenone.But the slowfrequency dependence of interventricular dispersion was not observed in same condition. CONCLUSION: Propafenone can significantly increase the interventricular repolarization heterogeneity in ischemic myocardium and make the slow-frequency dependence of interventricular dispersion disappear.It may be one of the electropharmacological mechanism of arrhythmogenic of propafenone in ischemic myocardium.

Key words: propafenone, repolarization dispersion, action potential, ischemia, arrhythmia

CLC Number:

965.2

GE Li-hua, LI Yun-tian, LI Cui-lan. Effects of propafenone on interventricular repolarization heterogeneity in ischemic myocardium in rabbits[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(3): 317-320.

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