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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2021, Vol. 26 ›› Issue (3): 332-340.doi: 10.12092/j.issn.1009-2501.2021.03.014

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Research progress on the mechanism of miRNA in intestinal ischemia-reperfusion injury

ZHANG Jianmin1, LENG Yufang1,2, LIU Xin1, REN Yixing1, SHI Yajing1, CHEN Feng1   

  1. 1 The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, Gansu, China; 2 Department of Anesthesiology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China
  • Received:2020-10-26 Revised:2021-01-17 Online:2021-03-26 Published:2021-04-06

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Abstract: microRNA (miRNA) is a class of 19-25 nucleotide highly conserved single-stranded non-coding RNA that is widely found in plants and animals. Their biological effect is to negatively regulate target gene expression at the post-transcriptional level through complementary pairing with mRNA. Intestinal I/R injury is more common in clinical practice, and ischemia-reperfusion will cause intestinal mucosal barrier damage, and it is related to the occurrence, development, and outcome of many clinical diseases. Many studies have shown that the miRNA subtype genes miR-34a-5p, miR-351-5p, miR-682, miR-21, etc. affect the intestinal I/R injury process to some extent by regulating a series of signal transduction. Therefore, revealing the role of miRNA in intestinal I/R injury and providing a new direction for the diagnosis and treatment of I/R.

Key words: miRNA, ischemia-reperfusion injury, intestinal injury, intestinal protection

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