Abstract: Irisin is an endogenous secreted muscle factor, which not only plays a certain clinical application value in a variety of metabolic diseases, cardiovascular and cerebrovascular diseases, neurological diseases, tumors and other diseases, but also affects the occurrence and development of organ ischemia/reperfusion injury. In this paper, the role and mechanism of irisin in organ ischemia/reperfusion injury were summarized, aiming to provide new ideas for prevention and treatment of organ ischemia/reperfusion injury.

Key words: irisin, organ ischemia/reperfusion, function, mechanism