Abstract: In recent years, new methods of defecation experiment in nonnal and constipated animal model have been successfully established in some species such as rats, rabbits, dogs and cynomolgus monkeys induced by several condition. This paper briefly introduced the progress in prepar of defecation in normal and constipated animal models, which was classified into two categories. (1) Drug-induced constipation animal models: Ftriptyline-induced constipation in cynomolgus monkeys, morphine-induced constipated rabbits, brimonidine and morphint induced atonic or spastic constipated ferrets, and loperamide-induced constipated rats and its colonic mucus decreased. (2) Defecation in normal animal models, including defecation in normal rabbits and dogs, measurement of gastrointestinal contractile activity in conscious monkeys. The paper reviewed the progress on methodology of constipated animal model which will be useful for the study on the anticonstipation drugs.

Key words: constipation, defecation, animal model, mucosa, gastrointestinal motility