Abstract: AIM: To obsene the eletes of tincazd-dine on nyrardial ischemia and heurt ate variability(HRV) in patients with non ST-elevalion acute comonarysymadroe (NSTEACS). METHODS: 74 patients withNSTEACS were chosen and ransiomly assiged into twugou one grop wa given orvratioal therapy wilh uae.pirin, isurhide mononitrate, fluvastatin and m fopokol,trimetazidine was akled on the base of coeveninal thera-py in the other group. The total obseralien lime of thera-py was 8 weeks. The heart rale, blood presure, frequency and penidene time of chesl pain, nuanden of tinesofusing Nitngyerin every day,tie exlent anl dke olmyo andial iseheria. HRV of plients were dored le.fore and after treatnen. RESULTS: The therapeutie ef-fect od inetaridie treatnert gorep(wilh the efetie rate 94.4%. exelleae rate 72.2%) was olviasly het-ler than tha ol the comentional treataen grap (with theffetive rale 65.8%. ecellence rale 36.8%)(P < 0.05 or P < 0.01). The SDNN, SDANN, MSSD an PNN50 of HRV wre significantly inereawed (P < 0.05);LF,LF/HF of HRV were sigpificanily decreaeed (P < 0.05) in trinstazidine Imeatnsent grsup whun eenpared with thene olf the cornventional treatment group (P < 0.05). CONCLUSION: Trinetazidine inpeovemyxandial ischemia am HRV in palienis with NSTEACS.

Key words: non-ST-elevation arute cernary syn-doee, irinrtaidine mymandial iebeutiai leart rale tari-ability