Abstract: AIM: To investigate the effets of Xing-naujing injection on serum cytokines in patients with severe pneunonia in ICU. METHODS: 40 patients with severe pneumonia in ICU were randkomly divided into two groups. 20 patients were infused Xingnaojing(XNJ group) and were treated with routine drugs and mnechanical venti-lation. Another in the control(C) group 20 patients were treated with drugs and mechanical ventilation. The noermal(N) group was consisted of 20 health oulpatients in thesame period. Tumor necrosis factor-a (TNF-α), inter-lukin-6(IL-6) and C-response protein(CRP) in plasmawere measured before aund after therapy in 40 patients withsevere pocumnia and in the nrmal group. RESULTS: The levels of TNF-α, IL-6 and CRP olf 40 patients were significantly higher than these in nmal penple(P < 0.05. P < 0.01). There was obviously lower level of TNF-α and lL-6 after therapy than before therapy in XNJ group and with dayS and(P < 0.05). But the level of CRP in all groups has no statistical significance. CONCLUSION: TNF-α and IL-6 are associated with in-flammakory reaction of the severe pneumonia. Xingnaojinginjection plays a lung injury poeetion role by reducing cytokine-mediated inflammalory response.

Key words: Xinguaojing injectien, ICU, severepneumwnia, cytokines, C-tespomse proten