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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2005, Vol. 10 ›› Issue (3): 259-264.

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Analysis of withdrawal of rofecoxib-cyclooxygenase-2 specific inhibitor

LI Qin, WANG Rui, CHEN Kun   

  1. Department of Clinical Pharmacology, Chinese PLA General Hospital, Beijing 100853, China
  • Received:2004-12-23 Revised:2005-01-27 Online:2005-03-26 Published:2020-11-18

Abstract: Rofecoxib, a COX-2 specific inhibitor, is approved for treatment of osteoarthritis, acute pain and primary dysmenorrhea.On September 30, 2004, Merck announced the voluntary worldwidewithdrawal of rofecoxib (Vioxx).This paper reviewed the pharmacological actions of the COX-2 specific inhibitors and the characterization, premarket study, clinical application and side-effects of rofecoxib and analyzed the withdrawal of rofecoxib.

Key words: rofecoxib, celecoxib, COX-2 inhibitor, cardiovascular effect, withdrawal

CLC Number: