Abstract: AIM: To investigate the antioxidative effects of phenolic alkaloids of Menispermum dauricum (PAMD)and its lowering lipid effects.METHODS: The effects of PAMD on spontaneous and induced liver homogenate lipid peroxidation were studied by TBA method for testing the content of MDA.Reactions of Fenton and Marklund were used to test the scavenging capacity of PAMD on superoxide anion and hydroxyl radicals.The lipid-lowering capacity of PAMD was observed on hyperlipidemic animal model.RESULTS: PAMD inhibited the production of MDA in spontaneous and induced peroxidation of liver homogenate.It also scavenged superoxide anions and hydroxyl radicals.CONCLUSION: PAMD can inhibit the lipid peroxidate in vitro, scavenge free radicals, lower the contents of TC, TG, LDL, and MDA in serum and liver and heighten the activity of SOD and the content of HDL in serum.

Key words: phenolicalk aloids of Menispermum dauricum, hyperlipidemic model, lipid peroxidate, antioxidant, oxygen free radicals, lipid