Research on relationship between interleukin-1 receptor antagonist and airway hyperresponsiveness

Abstract

Abstract: AIM: To explore the relationship between interleukin-1receptor antagonist (IL-1ra) and airway hyperresponsiveness (AHR) of asthma.METHODS: The airway responsiveness to inhaled histamine as PC20 was evaluated among the normal guinea pigs, and sensitized with ovalbumine (OA) and challenged 14 days later (athma group), and injected IL-lra 1 mg·kg^-1 intravenously 30 minutes before challenged (asthma plus IL-lra group).The numbers of different cells was counted and classified in bronchoalveolar lavage fluid (BALF).RESULTS: The PC20 of the asthma plus IL-1ra group was higher than that of asthma group (P<0.01), and the percentage of the neutrophils (NES) in BALF of the asthma plus IL-1ra group was lower than that of the asthma group (P<0.01).There was a significant correlation between -IgPC₂₀ and the percentage of the NES in BALF in all animals(r=0.68,P<0.001).CONCLSION: IL-1ra can attenuate airway hyperresponsiveness, possibly by decreasing the airway infiltration of neutrophils.

Key words: interleukin-1ra, asthma, airway hyperresponsiveness, neutrophils

CLC Number:

R965.1
R976

CHEN Xue-Qin, ZAO Xia, YANG Jiong, CAO Zuo-Yan. Research on relationship between interleukin-1 receptor antagonist and airway hyperresponsiveness[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(7): 759-762.

References

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