Research progress of the association between new inhibitory cytokines il-35 and bronchial asthma

doi:10.12092/j.issn.1009-2501.2018.02.021

Abstract

Abstract:

Asthma, while its pathogenesis remains unclear, is the most common chronic respiratory disease influenced by many factors including genetic and environmental influences. Classical theories believe that T helper cells(Th)1/Th2 cells are unbalanced, which further decrease Th1 cells response, and increase Th2 cells response. They cause allergen specific IgE secretion, airway eosinophils (EOS) infiltration, chronic airway inflammation and airway hyper-responsiveness (AHR). The findings of regulatory T cells (Tregs) and Th17 renew the understanding of the inflammatory mechanisms of asthma. The pathogenesis is no longer confined to the Th1/Th2 model. Like interleukin 12(IL-12), interleukin 35（IL-35）which belongs to the IL-12 family can effectively enhance the function of the Tregs and inhibit the proliferation and differentiation of Th17 cells, the excessive immune response, and immune damage to the body.It can be concluded that IL-35 could be involved and may play a protective role in the pathogenesis and regulation of asthma through a variety of pathways. This review introduces the biological characteristics of IL-35 and its role in the development and pathogenesis of asthma.

Key words: IL-35, asthma, Tregs, Th17

CLC Number:

R562.2

LV Ping, PENG Wansheng, DONG Huaifu. Research progress of the association between new inhibitory cytokines il-35 and bronchial asthma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(2): 230-234.

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