Influence of rofecoxib, a high selective cox-2 inhibitor, on articular cartilage of rats

Abstract

Abstract: AIM: To observe the influence of rofecoxib, a non-steroidal anti-inf lammatory drug, administrated for a long term on the knee joints cartilage of rats. METHODS: An experimental model of osteoarthritis of left knee in the early stage was induced by cutting achilles tendon in rats, the right knee providing a control.The rats of one group were given rofecoxib orally, and the rats in another group were given saline as a control.After 100 days, the histopathology, ultrastructure, and histochemistry changes on the knee joints cartilage were monitored. RESULTS and CONCLUSION: Rofecoxib, administrated for 100 days, had no harmful influence on chondrocyte and collagen, and could increase proteoglycan of cartilage in some degree in rats.

Key words: non-steroid anti-inflammatory drugs (NSAIDs), cartilage, osteoarthritis, rofecoxib, proteoglycan, chondrocyte

CLC Number:

R965.1

LIANG Xi, AN Hong. Influence of rofecoxib, a high selective cox-2 inhibitor, on articular cartilage of rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(3): 312-317.

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