Study on the mechanisms of Quyuningtong paster in treating acute soft tissue injury in rats

Abstract

Abstract: AIM: To study the mechanisms of Quyuningtong paster (QYNTP) in treating acute soft tissue injury in rats.METHODS: The models of acute soft tissue injury were established to observe the effects of QYNTP on the indexes of hemorheology in rats caused by strike, the rate of platelet aggregation and the thrombus formation in vitro.RESULTS: QYNTP (0. 3, 0. 9 and 1. 8 g·kg^-1) reduced the viscosity of whole blood, viscosity of plasma, content of fibrinogen, and packed volume of erythrocyte, slowed down the rate of erythrocyte sedimentation, reduced the K value in erythrocyte sedimentation rate equation, and shorten the erythrocyte electrophoresis time. It also inhibited the platelet aggregation and thrombus formation in vitro (P<0. 05 or P<0. 01).CONCLUSION: Improving the hemorheology and inhibiting the platelet aggregation and thrombus formation may be one aspect of the mechanisms of QYNTP in treating acute soft tissue injury in rats.

Key words: quyuningtong paster, acute soft tissue injury, hemorheology, platelet aggregation, thrombus formation

CLC Number:

R285.5

ZHANG Le-Zhi, MEN De-Sheng, WEN Bao-Shu, LU Jin-Sheng, WEI Bin. Study on the mechanisms of Quyuningtong paster in treating acute soft tissue injury in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(9): 1026-1029.

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