Protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (9): 1030-1032.

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Protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine

WANG Dan, YU Rong, LU Ying-Qing, YAO Ming-Hui

Department of Pharmacology, Shanghai Medical College, Fudan University, Shanghai 200032, China

Received:2004-04-02 Accepted:2004-07-22 Online:2004-09-26 Published:2020-11-23
Contact: YU Rong, male, Ph. D. , associate professor, engaged in neuropharmacology. Tel:021-54237228 E-mail:ryu @shmu. edu. cn
About author:WANG Dan, female, graduate student of Master Degree, engaged in neuropharmacology. Tel:021-64165314 E-mail:022101058 @fudan. edu. cn
Supported by:
Project supported by Natural Science Foundation of Shanghai (№02ZB14007)

Abstract

Abstract: AIM: To investigate the protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine.METHODS: Pharmacological model of amnesia inmice was induced by scopolamine. Memory result was evaluated by the stepthrough latency in the passive-avoidance task.RESULTS: Animals displayed marked decrease in the stepthrough latency after administration (scopolamine 1 mg·kg^-1, ip). Progesterone (1 mg·kg^-1, 10 mg·kg^-1, sc) and pregnenolone sulfate (1 mg·kg^-1, sc ) significantly decreased performance of animals in the passiveavoidance task.CONCLUSION: Progesterone and pregnenolone sulfate can ameliorate the memory deficit.

Key words: progesterone, pregnenolone sulfate, scopolamine, memory, passive-avoidance task

CLC Number:

R964

WANG Dan, YU Rong, LU Ying-Qing, YAO Ming-Hui. Protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(9): 1030-1032.

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Protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine

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