Abstract: AIM: To evaluate the efficacy and safety of xindakang capsules in the treatment of patients with angina pectoris.METHODS: Diaoxinxuekang capsule was taken as a control agent, and xindakang capsule was observed in a random, positive drug parallel contrast, multicenter clinical trail.RESULTS: Xindakang capsule significantly relieved the symptoms of angina pectoris, and reduced the number of times of attack of angina and the doses of nitroglycerin(P<0. 01).The total effective rate of xindakang capsules was 85. 6 %on the symptoms of the traditional Chinese medicine, such as chest pain (88. 9 %), palpitation (84. 8 %), ECG (60. 0 %).The marker of hemorheology, blood viscosity and PCV decreased(P<0. 01)in xindakang group, and the fibrinogen also decreased(P >0. 05).No serious side effects were found on blood-routine, urine-routine, stool-routine, liver function and kidney function in the two groups.CONCLUSION: Xindakang capsule is an effective and safe drug in treating angina pectoris.

Key words: xindakang capsule, angina pectoris, TCD therapy, adverse drug reaction, clinical trail