Anti-oxidative effect of total extract of astragalus(TEA)on aging mice

Abstract

Abstract: Aim To study the mechanism of the anti-aging effect of total extract of astragalus(TEA) in mice.Methods MDA content, the activities of Mn-SOD and GSH_px and the reduced to oxidized glutathione (GSH/GSSG)ratio in mitochondria of D-galactose(D-gal)treated mice and 17-month-old mice were measured.Results Treatment with TEA(40 mg·kg^-1·d^-1ig)for 10wk would lower the content of MDA and restore activities of Mn-SOD, GSH_pxand GSH/GSSG ratio in mitochondria of D-gal treated mice.Treatment with TEA (40mg·kg^-1·d^-1 ig)for 3 mon had the same effect on 17-month-old mice.Conclusion TEA has anti-aging effect on D-gal treated mice and 17-month-old mice significantly, probably being related to its anti-oxidative effect.

Key words: astragalus, aging, D-galactose, LPO, GSH_px, Mn-SOD, glutathione

CLC Number:

R965

LEI Hong, WANG Bin, LI Wei-Ping, YANG Yan, ZHOU Ai-Wu, CHEN Min-Zhu. Anti-oxidative effect of total extract of astragalus(TEA)on aging mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2000, 5(4): 298-301.

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