Abstract: Aim To observe the effect of interventional therapy of 5-fluorouracil(5-Fu), mitomycin C(MMC)and adriamycin (ADM)on solid malignant turmors in association with aterial infusion of NaHCO₃.Methods Patients were randomly divided into two groups.With Seldinger technique, through the femoral atery to tumoratery.The patients in the control group were infused by anticarcinoma agents simply, and patient s in the treatment group were initially infused by NaHCO₃, and then by NS 30 ml and anticarcinoma agents seperately. Results Partial remission (PR)in the group treated with NaHCO₃ and anticarcinoma agents was significantly higher than in the group treated simply with anticarcinoma agents.Conclusion Aterial infusion of NaHCO₃ into malignant tumors can increase the efficacy of ADM,MMC and 5-Fu.