Abstract: AIM: To evaluate the efficacy and safety of domestic trimebutine in the treatment of functional dys-pepsia.METHODS: As an open multicenter study, the inclusion criteria were the patients with early satiety and bloating which might accompany with nausea, vomiting, abdominal pain, heartburn, anorexia, belch, and the du-ration >12 weeks.Trimebutine was used in these pa-tients for 2weeks.The symptoms, including nausea, vom-iting, abdominal pain, heartburn, early satiety and bloat-ing, anorexia, belch, and bad apetite were observed be-fore and after the treatment.The degree of above symp-toms were classified into no, mild, moderate and severe. The some aboratory indexeswere also tested before and af-ter the treatment.RESULTS: 86 patients completed the whole study by per protocol analysis.The total improved rate were (67.64±23.91) %.There had significant im-provement for the main symptoms like early satiety and bloating (P<0.01).The effective rate of early satiety was 72.7%, bloating was 84.7%, and the rate of side effect was 3.49%.CONCLUSION: Domestic trimebu-tine is effective and safe to treat functional dyspepsia.

Key words: trimebutine, functional dyspepsia sufe-ty, efficacy