Abstract: AIM: To study chemosensitivity in vitro and therapeutic effects of chemotherapy in the patients with stomach cancer.METHODS: Chemosensitivity in vitro of 98 cases with gastric cancer was determined by modified MTT method and chemotheraputic regimen was selected according to the results of chemosensitivity. Therapeutic effects on gastric cancer for the shot term and long term were studied.RESULTS: The chemosensitivity order of drugs in 98 cases with gastric cancer was cis-platin, mitomycin, doxorubicin, etoposide, fluorouracil, cytarabine, vincristin, and methotrexate, andwas consis-tent with effective drugs for gastric cancer proved by clini-cal practice.The total coincidence rate of chemosensitivi-ty in vitro and therapeutic effects for short term was 81.8%(18/22).The survival rate of three years and of five years for Ⅱ, Ⅲ phase gastric cancer in chemosensi-tivity test group were 62.5% and 52.8%, respectively, which were higher than those in control group. CONCLUSION: Chemotherapy under the guidance of chemosensitivity in vitro can improve the long term sur-vival rate of gastric cancer, especially advanced gastric cancer.

Key words: MTT assay, gastric cancer, chemother-apy, chemosensitivity