Abstract: Aim The effects of antibiotics and anticoagulants on mouse peritonaeum were observed to explore the factor of the peritoneal dialysis related sclerosing peritonitis. Methods The experimental models of peritoneal dialysis were established in mice by infusing different kind of drugs to the peritoneal cavity and the changes of the peritoneal membrane for each drug at different time were observed by the autopsy and light microscope for several weeks.Results Amikacin, Cefradine, Zinacef, Ciprofloxacin, Heparin and Urokinase could induce sclerosing changes of peritoneal membrane such as loss of peritonel mesothelum ifltration of ilammaory clls and of polirntion ibrcell.Thee changes were ireresrible efter the drugs were stoped.Conclusion The drugs commonly used in prioneal dalysis may in dfen deree resul in peioneal sclerosis.

Key words: drug, pritoeal dalys, peioneal sclerosis