Abstract: Aim To probe the effect of bambuterol on experimental asthma and its pharmacody namic and pharmacokinetic chracteristics, as w ell as its mechanism. Methods Experimental asthma model on guinea pigs was induced by histamine and ovalbumin in vivo and their t rachea f lake and pulmonary bar were emptied to the research in vi tro respectively.Results Bambuterol inhibited asthma induced by histamine and ovalbumin in guinea pigs in a dose-dependent manner. Bambuterol gave no relaxation to all t rachea f lake, but the int ragast ric gavage (ig) of plasma of the bambuterol-treated g uinea pig s relaxed t rachea f lake and pulmonary bar, and the effect on pulmonary bar was st ronger than that on t rachea f lake.The peak value appeared about 4 h after administration, and the action continued for more than 24 h.Conclusion Bambuterol as pro-drug of terbutaline metabolized in body has a mild and permanent effect on the model of experimental asthma in g uinea pig s.

Key words: bambuterol, terbutaline, asthma, guinea pigs