Therapeutic effect of tea polyphenols on cationic bovine serum albumin glomerulonephritis in rabbits1

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2002, Vol. 7 ›› Issue (3): 217-220.

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Therapeutic effect of tea polyphenols on cationic bovine serum albumin glomerulonephritis in rabbits¹

HONG Zong-Yuan, ZHENG Qing-Shan², GUI Chang-Qing³, SONG Jian-Guo³, SUN Rui-Yuan²

School of Life Science, University of Science and Technology of China, Hefei 230027;
²Anhui Provicial Center for Drug Clinical Evaluation, Wuhu 241001;
³Department of Pharmacology, Wannan Medical College, Wuhu 241001

Received:2001-10-18 Revised:2001-01-07 Published:2020-12-01
Contact: HONG Zong-Yuan, correspondent, male, Ph.D, associate professor, main re-search fieldis renal pharmacology and pharmacogenomics. Tel:86-551-3655324 E-mail:zongyhong @163.net.
Supported by:
1 Natural Scientific Foundation of Anhui Province (No 98444332) and the Educational Foundation of Anhui Province (No 98JL042).

Abstract

Abstract: AIM: To investigate the therapeutic effect of tea polyphenols (TP) on cationic bovine serum albumin (C-BSA) glomerulonephritis.METHODS: C-BSA glomerulonephritic model was inducedin rabbits.TP in three different doses (30, 100 and 300 mg·kg^-1) was ad-ministered (ig) once daily for 14 days.RESULTS: TP not only significantly reduced the urinary protein excretion, decreased blood urea nitrogen (BUN) and plasma creati-nine (Cr) levels, but also significantly relieved gloermular lesions in the rabbits treatedand there was a significant dose-dependent relationship between high dosage (300 mg·kg^-1) and low dosage (30 mg·kg^-1).CONCLUSION: TP can reduce proteinuria, suppress the development of glomerular impairments, and ameliorate the kidney function of rabbits with C-BSA glomerulonephritis.

Key words: tea polyphenols, C-BSA glomeru-lonephritis, rabbit, animal model

CLC Number:

R965.1

HONG Zong-Yuan, ZHENG Qing-Shan, GUI Chang-Qing, SONG Jian-Guo, SUN Rui-Yuan. Therapeutic effect of tea polyphenols on cationic bovine serum albumin glomerulonephritis in rabbits¹[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(3): 217-220.

References

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Therapeutic effect of tea polyphenols on cationic bovine serum albumin glomerulonephritis in rabbits¹

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