Abstract: AIM: To observed clinical effect and safety of perindopril alone and combined with gliclazide in the treatment of type Ⅱdiabetic with hypertension and di-abetic nephropaphy (DN).METHODS: 61 patients (male 34, female 27) were randomly dividedinto 2 groups. Perindopril group (n =31):perindopril 4 mg qd, and gliclazide 80 mg bid.Nifedipine group (n = 30):nifedipine 10 mg qd, and gliclazide 80 mg bid.The treatments lasted for three months.RESULTS: After the treatments, the levels of blood pressure, FPG, and GHb were distinctly reducedin the two groups (P<0.05), but the marked differences did not show between the two groups (P >0.05).In perindopril group, the urine min-im albumin (UMA) was markedly reduced (P<0.01), but nifedipine group was not changed.The values of + WBC, RBC, PLT, Ure, Cr and K in the two groups were not changed before and after the treatments.CONCLUSION: Perindopril is safe and effective in the treat-ment of the type Ⅱdiabetic with hypertension and diabetic nephropaphy.The agent can obtain a better effect in com-bination with gliclazide than alone.

Key words: nephropaphy, nifedipine, perindopril, urine minim albumin