Abstract: AIM: To observe the effect the combina-tion of hydrobromidum (654-2) and salviae miltiorrhizae on diabetic peripheral neuropathy (DPN).METHODS: sixty-two cases of DPN were given the normal treatment of diabetes.Based on the treatment, they were dividedinto three groups at random.The first group (n =24) was given the combinction 654-2 and salviae miltiorrhizae, the second group (n =20) was given 654-2 alone, and the third group (n =18) was given salviae miltiorrhizae alone.RESULTS: The effertiverates in the first, the secondand the third group were 79.2 %, 45 % and 27.8 % (P<0.05), respectively, while the effectiverate were 100 %, 85 % and 61.1 %, respectively (P<0.05).CONCLUSION: Combination of 654-2 and salviae miltiorrhizae has a good effect to DPN.

Key words: diabetic peripheral neuropathy, hydro-bromidum, salviae miltiorrhizae, microcirculation