Abstract: Aim The study was aimed to investigate the nechanism of anticoagulant in reducing urinary albumin excreling rate (UAER). Methods Fifty-eight patients at their microalbuminuria stage of NIDDM (H stage of DN) were treated by anticoagulant (acid acetylsalicylic enter-solubilis and dipyridamole). The relationship between UAER and hypercoagulability was ob-served before and after treatment. Results It was found that anticoagulant significantly reduced UAER. With improvement of hypercoagulability, UAER was decreased remarkably (P<0.05). Conclusion Dipyridamole and acid acetylsalicylic entersolubilis are easy,effi-cient and safe drugs for redycing UAER of DN.

Key words: Anticagulant, Diabetic nephropathy