Abstract: Aim The effect of insulin on the vasocontrictive agents including noradrenaline, endothe-lin-1, KCI, angiotensin II and 5-hydroeytryptamine, was analysed. Methods Aortic rings of SD rats were used to investigate the influence of insulin for several vasocontrictive agents. Results Insulin was hypersensitive for noradrenaline, endothelin-1 and KCL, and incresed the effects of angiotensin II but no difference, buc had no effect on 5 ~ hy-droxytrypramine. Conclusion It suggests insulin could play an Important role in occurrence of hypertension.

Key words: insulin, vasocontriction, hypersensitivity