Welcome to Chinese Journal of Clinical Pharmacology and Therapeutics,Today is Chinese

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (5): 586-589.

Previous Articles     Next Articles

Study on absorption and distribution of oxybutynin oral tablet and transdermal gel in rats

WEN Qing, FENG Kun1, GUO Rui-chen2   

  1. Pharmacy of Jinan Central Hospital, Jinan 250013, Shandong, China;
    1Pharmacy of the Second Affiliated Hospital, Shandong Traditional Chinese Medicine University, Jinan 250001, Shandong, China;
    2Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2006-01-18 Accepted:2006-02-27 Online:2006-05-26 Published:2020-12-09
  • About author:WEN Qing, female, master, engaged in clinical pharmacology. Tel:13335190878 E-mail:zhong9942@sina.com

PDF (PC)

97

Abstract: AIM: To study the absorption and distri-bution characteristics of oxybutynin (OXY) oral tablet and transdermal gel.METHODS: A single dose of 0.1 g OXY transdermal gel (2mg OXY) was applied to abdom-inal area about 4 cm2 and 0.5mg immediate-release tablet was orally given to 48 rats in a randomized, open-label, control design test.The plasma, bladder and liver tissue were collected, disposed and analyzed and OXY pharma-cokinetic parameters were calculated and evaluated.RESULTS: The Cmax of OXY transdermal gel and oral table-ts in bladder are approximately 800 and 70 times higher than those in plasma.The plasma half life of OXY gel de-layed 5.99 h, tablets 2.18 h.CONCLUSION: OXY gel show better pharmacokinetic properties, characterized with long half life and high target organ concentrations than those of tablets.

Key words: oxybutynin, transdermal gel, pharmaco-kinetics, HPLC-MS, rats

CLC Number: