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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2020, Vol. 25 ›› Issue (12): 1429-1435.doi: 10.12092/j.issn.1009-2501.2020.12.016

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New progress in drug prevention and treatment of migraine

YANG Xinyi, ZHANG Jing, LI Nanyang, YANG Haijing, MAO Xiaomeng   

  1. Phase I Unit, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2020-08-21 Revised:2020-10-14 Online:2020-12-26 Published:2021-01-04

Abstract: Migraine is a common nervous system disease, which could seriously affect the quality of life. However, the medical treatment of migraine cannot meet the clinical needs at present. With the deepening of research, serotonin 1F receptor agonists and drugs targeting CGRP are more and more developed and marketed. In this paper, the mechanism of action, safety and efficacy, metabolic characteristics of these drugs were systematically evaluated to provide a more scientific basis for clinical prevention and treatment of migraine. 

Key words: migraine, monoclonal antibody against CGRP, pharmacokinetics

CLC Number: