Abstract: With an improvement in the long-term survival rates of cancer patients,  the requirements for fertility protection of young cancer patients after chemotherapy are increasingly prominent. Early studies have shown that gonadotropin-releasing hormone agonist (GnRHa) has a protective effect on fertility. But in recenct year, relevant studies have shown that its protective effect is controversial. This article reviews the clinical researches of GnRHa for fertility protection in patients with common tumors, and explores its evidence-based medicine, in the hope of providing references for reasonable clinical application.

Key words: gonadotropin-releasing hormone agonists (GnRHa),  , fertility protection, chemotherapy, evidence-based medicine