Progress on ChemR23 and its ligands

Abstract

Abstract: Recently,the relationship of the microenvironment and the tumor metastasis has become a new research focus.Multiple evidences reveal that the regulations of the tumor microenvironment enable the inhibition of metastasis, advanced research suggest that the chemokine-like receptor 1 (CMLR1 also ChemR23 )and its ligands in signal transduction and cell-cell interaction in the regulations of the tumor microenvironment play an important role. Therefore,ChemR23 and its signal pathway might be a new target for cancer therapy.

Key words: Inflammation, Tumor metastasis, ChemR23, Chemerin, ResolvinE1 (RvE1)

CLC Number:

R73
Q291

WAN Jiang-bo, WANG Qi-zhao, XU Rui-an. Progress on ChemR23 and its ligands[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(2): 219-225.

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