Progress in the roles of adenosine receptors in sleep-wake regulation

Abstract

Abstract: Adenosine, the product of ATP, widely presented in the brain is proposed to be an endogenous sleep-promoting substance. Among 4 subtypes of adenosine receptor (R), A₁R, A_2AR, A_2BR and A₃R, it has been reported that both adenosine A₁R and A_2AR mediate the somnogenic effects of adenosine. Activation of A₁R in the arousal histaminergic posterior hypothalamus, cholinergic basal forebrain and so on promotes sleep. A_2AR is mainly localized in the caudate-putaman, nucleus accumbens, olfactory tubercles. Activation of A_2AR significantly promotes sleep. A_2AR mediates the somnogenic effects of prostaglandin D₂, and acts as the target of caffeine. However, the roles of A₁R and A_2AR in sleep-wake regulation are in debate. This review summarizes the progress in the roles of adenosine receptors in sleep-wake regulation.

Key words: Neurobiology, Adenosine receptor, Basal forebrain, Prostaglandin D₂, Sleep

CLC Number:

R749

YU Jie, XU Qi, WANG Yi-qun. Progress in the roles of adenosine receptors in sleep-wake regulation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(2): 214-218.

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