Abstract: AIM: To explore the protective effect of Selaginella moellendorfii Hieron on experimental hepatic fbrosis rat. METHODS: Hepatic fibrosis model was made by subcutaneous injection 50% carbon tetrachloride (CCl₄) for 8 weeks,and then were intragastric administered with total flavonoids of Selaginella moellendorfii Hieron suspension(15,30,60 mg/kg),silybin was experimental control group.All rats were killed after 8 weeks,the score of hepatic fibrosis and the index in liver tissue and serum were evaluated. RESULTS: The result showed that the hepatic fibrosis was in III-IV stage. Compared with the model group,total flavonoids of Selaginella moellendorfii Hieron could significantly decrease the levels of ALT,AST in serum,and the MDA in liver tissue,and increase the level of SOD.The pathomorphology of hepatic fibrosis rat was improved. CONCLUSION: Total flavonoids of Selaginella moellendorfii Hieron have a better protective effect on rat hepatic fibrosis induced by CCl₄.

Key words: Hepatic fibrosis, Carbon tetrachloride, Selaginella moellendorfii Hieron, Flavonoids