Abstract: AIM: To study the influence of qiye xinkang capsule (QXC) on the cerebral ischemia-reperfusion injury in rats. METHODS: Aften the model of cerebral ischemia-reperfusion injury in rats was simulated successfully by string occlusion, protective effect of QXC on cerebral ischemia-reperfusion injury was evaluated by neurofunctional score, red tetrazoline (TTC) and weighing method.The mechanism was investigated by determining the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), nitric oxide (NO) and malondialdehyde (MDA) from rat hippocampus homogenate. RESULTS: The rats replicated successfully were orally administered with QXC for four times: 1 h for the first time, 12 h for the second time, 24 h for the third time and 36 h for the forth time.The neurological deficit and brain infarction area resulted from cerebral ischemia in rats were improved significantly,meanwhile the water content and content of MDA and NO were decreased significantly and the activity of SOD and GSH-Px was increased significantly in the tissue of cerebral ischemia in dose of 271.3 and 135.6 mg/kg. CONCLUSION: QXC had notable protective effect on cerebral inchemia-reperfusion injury in rats, which might be related with inhabiting the lipid peroxidation of the brain tissue and reducing the generate of the NO.

Key words: Qiye xinkang capsule, Cerebral ischemia-reperfusion injury, Protective effect