Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2011, Vol. 16 ›› Issue (4): 474-480.
WANG Ping, LIU Xiao-dong
Received:
2011-03-08
Revised:
2011-03-22
Published:
2011-06-22
CLC Number:
WANG Ping, LIU Xiao-dong. Cytochrome P450s and the metabolism of vitamin A[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(4): 474-480.
[1] Aranda A, Pascual A. Nuclear hormone receptors and gene expression [J]. Physiol Rev, 2001, 81(3): 1269-1304. [2] Kiefer C, Hessel S, Lampert JM, et al. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A [J]. J Biol Chem, 2001, 276(17): 14110-14116. [3] Ross AC, Zolfaghari R. Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status [J]. J Nutr, 2004, 134(1): 269S-275S. [4] Luo T, Sakai Y, Wagner E, et al. Retinoids, eye development, and maturation of visual function [J]. J Neurobiol, 2006, 66(7): 677-686. [5] Pierre, C. A decade of molecular biology of retinoic acid receptors [J]. FASEB J, 1996, 10(9):940-954. [6] Andreola F, Fernandez-Salguero PM, Chiantore MV, et al. Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism [J]. Cancer Res, 1997, 57(14): 2835-2838. [7] Schmidt CK, Hoegberg P, Fletcher N, et al. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the endogenous metabolism of all-trans-retinoic acid in the rat [J]. Arch Toxicol, 2003, 77(7): 371-383. [8] Chen H, Howald WN, Juchau MR. Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes [J]. Drug Metab Dispos, 2000, 28(3): 315-322. [9] Zhang QY, Dunbar D, Kaminsky L. Human cytochrome P-450 metabolism of retinals to retinoic acids [J]. Drug Metab Dispos, 2000, 28(3): 292-297. [10] Raner GM, Vaz AD, Coon MJ. Metabolism of all-trans, 9-cis, and 13-cis isomers of retinal by purified isozymes of microsomal cytochrome P450 and mechanism- based inhibition of retinoid oxidation by citral [J]. Mol Pharmacol, 1996, 49(3): 515-522. [11] Yang YM, Huang DY, Liu GF, et al. Inhibitory effects of vitamin A on TCDD-induced cytochrome P-450 1A1 enzyme activity and expression [J]. Toxicol Sci, 2005, 85(1):727-734. [12] Wanner R, Panteleyev A, Henz BM, et al. Retinoic acid affects the expression rate of the differentiation-related genes aryl hydrocarbon receptor, ARNT and keratin 4 in proliferative keratinocytes only [J]. Biochim Biophys Acta, 1996, 1317(2): 105-111. [13] Arnhold T, Elmazar MM, Nau H. Prevention of vitamin A teratogenesis by phytol or phytanic acid results from reduced metabolism of retinol to the teratogenic metabolite, all-trans-retinoic acid [J]. Toxicol Sci, 2002, 66(2): 274-282. [14] McSorley LC, Daly AK. Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation [J]. Biochem Pharmacol, 2000, 60(4): 517-526. [15] Marill J, Cresteil T, Lanotte M, et al. Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites [J]. Mol Pharmacol, 2000, 58(6): 1341-1348. [16] Liu C, Russell RM, Seitz HK, et al. Ethanol enhances retinol acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1. Gastroenterology, 2001, 120(1): 179-189. [17] Liu C, Chung J, Seitz HK, et al. Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed rats [J]. Alcohol Clin Exp Res, 2002, 26(11): 1703-1709. [18] Saadeddin A, Torres-Molina F, Cárcel-Trullols J, et al. Effect of cytochrome P450 inhibitors (diethyl dithiocarbamate, ketoconazole and grapefruit juice) on the pharmacokinetics of all-trans-retinoic acid [J]. Farmaco, 2004, 59(9): 697-702. [19] Lacroix D, Sonnier M, Moncion A, at al. Expression of CYP3A in the human liver-evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth [J]. Eur J Biochem, 1997, 247(2): 625-634. [20] Trofimova-Griffin ME, Brzezinski MR, Juchau MR. Patterns of CYP26 expression in human prenatal cephalic and hepatic tissues indicate an important role during early brain development [J]. Brain Res Dev Brain Res, 2000, 120(1): 7-16. [21] Thatcher JE, Zelter A, Isoherranen N. The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid [J]. Biochem Pharmacol, 2010, 80(6): 903-912. [22] Ocaya PA, Elmabsout AA, Olofsson PS, et al. CYP26B1 plays a major role in the regulation of all-trans-retinoic acid metabolism and signaling in human aortic smooth muscle cells [J]. J Vasc Res, 2011, 48(1): 23-30. [23] Taimi M, Helvig C, Wisniewski J, Ramshaw H, et al. A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid [J]. J Biol Chem, 2004, 279(1): 77-85. [24] Adedoyin A, Stiff DD, Smith DC, et al. All-trans-retinoic acid modulation of drug-metabolizing enzyme activities: investigation with selective metabolic drug probes [J]. Cancer Chemother Pharmacol, 1998, 41(2): 133-139. [25] Xi J, Yang Z. Expression of RALDHs (ALDH1As) and CYP26s in human tissues and during the neural differentiation of P19 embryonal carcinoma stem cell [J]. Gene Expr Patterns, 2008, 8(6): 438-442. [26] Cai Y, Dai T, Ao Y, et al. Cytochrome P450 genes are differentially expressed in female and male hepatocyte retinoid X receptor alpha-deficient mice [J]. Endocrinology, 2003, 144(6): 2311-2318. [27] Howell SR, Shirley MA, Ulm EH. Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid x receptor selectivity and effects on metabolic enzymes [J]. Drug Metab Dispos, 1998, 26(3): 234-239. [28] Chen S, Wang K, Wan YJ. Retinoids activate RXR/CAR-mediated pathway and induce CYP3A [J]. Biochem Pharmacol, 2010, 79(2): 270-276. [29] Wang K, Chen S, Xie W,et al. Retinoids induce cytochrome P450 3A4 through RXR/VDR-mediated pathway [J]. Biochem Pharmacol, 2008, 75(11): 2204-2213. [30] Tay S, Dickmann L, Dixit V, et al. A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation [J]. Mol Pharmacol, 2010, 77(2): 218-227. [31] Tay S, Dickmann L, Dixit V, et al. A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation [J]. Mol Pharmacol, 2010, 77(2): 218-227. [32] Wan YJ, Cai Y, Lungo W, et al. Peroxisome proliferator-activated receptor alpha-mediated pathways are altered in hepatocyte-specific retinoid X receptor alpha-deficient mice [J]. J Biol Chem, 2000, 275(36): 28285-28290. [33] Lou YR, Miettinen S, Kagechika H, et al. Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells [J]. Biochem Biophys Res Commun, 2005, 338(4): 1973-1981. [34] Szanto A, Benko S, Szatmari I, et al. Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages [J]. Mol Cell Biol, 2004, 24(18): 8154-8166. [35] Johnson EF, Palmer CN, Griffin KJ, et al. Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation [J]. FASEB J, 1996, 10(11): 1241-1248. [36] Attie AD, Kastelein JP, Hayden MR. Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis [J]. J Lipid Res, 2001, 42(11): 1717-1726. [37] Wang N, Ranalletta M, Matsuura F, Peng F, Tall AR. LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL [J]. Arterioscler Thromb Vasc Biol, 2006,26(6): 1310-1316. [38] Cui H, Okuhira K, Ohoka N, et al. Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRalpha/RXR [J]. Biochem Pharmacol, 2011, 81(6): 819-824. [39] Takatori A, Akahori M, Kawamura S, Itagaki S, Yoshikawa Y. The effects of diabetes with hyperlipidemia on P450 expression in APA hamster livers [J]. J Biochem Mol Toxicol, 2002, 16(4): 174-181. |
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