Effects of polymorphic gene on the pharmacokinetics and pharmacodynamics of amlodipine

Abstract

Abstract: Amlodipine, 1,4-Dihydropyridine calcium channel antagonists, prescribed in the management of angina and hypertension, act as substrates of CYP3A5, has a pharmacokinetic profile that differs from other dihydropyridines.It has been suggested that the CYP3A5^*3 allele contributes to the interindividual variability of CYP3A activity in vivo. This review aimed to summarize the clinical application of the amlodipine and the possible role of the genetic polymorphism CYP3A5 on the pharmacokinetics and pharmacodynamics of amlodipine and instruct the reasonable clinical application of amlodipine.

Key words: CYP3A5, Amlodipine, Pharmacokinetics, Pharmacodynamics

CLC Number:

R969

YANG Xia-ling,YANG Jing-zhi, XIONG Yu-qing. Effects of polymorphic gene on the pharmacokinetics and pharmacodynamics of amlodipine[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(4): 455-460.

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