Abstract: AIM: To study the effect of ajoene on thrombosis in rats. METHODS: SD rats were randomly divided into five groups according to body weight: normal control group, Panax notoginseng Saponins group (50 mg/kg), and ajoene groups (25, 50, 75 mg/kg). Rats were given drugs everyday for 5 days, 2 h after the last administration using model of ligation of the inferior vena cava, FeCl₃ induced thrombosis and cuticle bleeding time to text the antithrombotic effect. Meanwhile collect blood plasma to text pronthrombin time (PT), thromboplastin time (APTT). RESULTS: Ajoene could inhibit the formation of arterial and venous thrombosis, and inhibition rates of high dose ajoene on thrombosis of the arteriovenous were more than 40%. And it also could significantly increase the cuticle bleeding time, prolong the levels of PT, APTT(P<0.05). CONCLUSION: Ajoene can inhibit experimental arterial and vein thrombosis. And it has the satisfactory effect on anti-thrombosis.

Key words: Ajoene, Antithrombotic, PT, APTT, Rats