Abstract: AIM: To investigate the analgesic effects of parecoxib sodium patient after surgery.METHODS: 100 patients undergoing surgery were randomly divided into two groups (n=50):group P(parecoxib sodium combined with PCEA) and group C(tramadol 0.5 g combined with PCEA).All patients received PCEA after surgery respectively.VAS(visible analgesia score) was performed within postoperative 4,6,8,12 and 24 hours respectively,meanwhile,using frequency of PCA and the side effects were recorded as well.The levels of IL-6,TNF-α were detected at each time spots.RESULTS: Within postoperative 4,6,8,12 and 24 hours,the VAS scores were all less in group P than those in group C(P<0.05).The using frequency of PCA and the side effects were all less in group P than those in group C within 24 hours(P<0.05).CONCLUSION: Parecoxib combined with PCEA after anorectic surgery has better analgesia effects and less side reactions.It reduces the ascension of IL-6,TNF-α in the perioperative period.

Key words: Parecoxib sodium, Patient controlled epidural analgesia, Surgery, Analgesia, Adverse reaction