Protection of volatile oil from Angelica sinensis on focal cerebral ischemia-reperfusion in rats

Abstract

Abstract: AIM: To discuss the protection of volatile oil from Angelica sinensis on focal cerebral ischemia-reperfusion in rats. METHODS: Focal cerebral ischemia-reperfusion injury model was made with suture-occluded method.The neurological deficits of rats were observed after occluding middle cerebral artery for 45 min and reperfusion for 2 hours.The volume of cerebral infarction were measured; the levels of NOS and NO, and the activities of SOD and GSH-Px in serum were detected. RESULTS: Volatile oil from Angelica sinensis could effectively ameliorate the changes induced by cerebral ischemia-reperfusion, including: meliorate the neurological deficits; decrease the levels of NOS and NO and the volume of cerebral infarction; increase the activities of SOD and GSH-Px. CONCLUSION: Volatile oil from Angelica sinensis shows the protection against ischemia-reperfusion injury, and the effect may related to increase antioxidation of the brain tissue.

Key words: Volatile oil from Angelica sinensis, Cerebral ischemia-reperfusion injury, NO, NOS, SOD, GSH-Px

CLC Number:

R965.2

LUO Hui-ying, YANG Lin, YANG Huan, LIU Yuan. Protection of volatile oil from Angelica sinensis on focal cerebral ischemia-reperfusion in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(4): 387-391.

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