Abstract: AIM: To investigate the interventional effect of puerarin combined with compound salvia injection on neurological function of patients with acute hypertensive intracerebral hemorrhage. METHODS: Two hundred patients with acute hypertensive intracerebral hemorrhage were randomly divided into control group, puerarin group, compound salvia group and combined treatment group. Control group received ordinary therapy, puerarin group received additional puerarin injection based on ordinary therapy, compound salvia group received additional compound salvia injection based on ordinary therapy and combined treatment group received additional puerarin and compound salvia injection based on ordinary therapy. Each group had been treated continuously for two weeks. Hematoma volume and brain edema index were calculated. Plasma C-reactive protein and D-dimer concentrations were measured. And National Institutes of Health Stroke Scale score and Barthel score were recorded.RESULTS: Using analysis of variance for factorial design, hematoma volume and brain edema index in combined treatment group were markedly lower than those in other three groups at day 14 post-treatment (all P<0.05). At day 7 and 14 post-treatment, plasma C - reactive protein and D - dimer concentrations in combined treatment group were obviously lower than those in other three groups (all P<0.05). At 3 month post-treatment, NIHSS scores in combined treatment group were obviously lower than those in other three groups (all P<0.05) and BI scores in combined treatment group were obviously higher than those in other three groups (all P<0.05). CONCLUSION: A positive synergistic interaction between puerarin and compound salvia injection was demonstrated and can benefit the improvement of neurological function after acute hypertensive intracerebral hemorrhage.

Key words: Hypertensive intracerebral hemorrhage, Puerarin, Salvia miltiorrhiza, Neurological function