The advances of plasmacytoid dendritic cells (pDCs) in chronic hepatitis B

Abstract

Abstract: Hepatitis B virus (HBV) cannot be effectively cleared in patients with chronic HBV infection, which involves complex mechanisms. The immunosuppression is a very important reason. Dendritic cells play a central role in antigen presentation and activating specific immunity. Many studies have shown that dendritic cells cleared of the virus and defended against tumor through activation of adaptive immune responses. Plasmacytoid dendritic cells (pDCs), a subtype of dendritic cells, plays an important role in the process of anti-virus due to its production of high levels of type I interferon and amplification of the immune against pathogens. Moreover, pDCs appeared to be defective in number and function in chronic hepatitis B (CHB) patients, which may be associated with viral clearance and persistence. This review resumes the basic functions and mechanisms of pDCs may be involved in chronic hepatitis B.

Key words: Hepatitis B virus, Plasmacytoid DC, Type I interferon

CLC Number:

R512.6⁺2

TANG Yu-yan, LI Dan, YU Yong-sheng. The advances of plasmacytoid dendritic cells (pDCs) in chronic hepatitis B[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(9): 1062-1066.

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