Genetic polymorphism of CYP2D6 and its influence on the personalized usage of antipsychotics

Abstract

Abstract: CYP2D6 is one of the most important cytochrome P450 enzymes. There is remarkable genetic polymorphism of CYP2D6. CYP2D6 play an important role in the metabolism of antipsychotics, and has significant correlation with the inter-individual difference of pharmacokinetics and pharmacodynamics of antipsychotics. Determination of CYP2D6 genotypes is helpful in the selection and regulation of antipsychotic therapy regimen for the elevation of efficiency and safety. The influence of CYP2D6 genetic polymorphism on the pharmacokinetics, adverse effect and drug-drug interaction was reviewed and the usefulness of CYP2D6 genotyping in the personalized antipsychotic therapy was discussed.

Key words: CYP2D6, Genetic polymorphism, Antipsychotics, Pharmacokinetics, Adverse drug reaction

CLC Number:

R969

CHEN Bing, CAI Wei-min, YANG Wan-hua. Genetic polymorphism of CYP2D6 and its influence on the personalized usage of antipsychotics[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(9): 1067-1074.

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