Research progress of glucagon-like peptide-1 and analogues on blood pressure

Abstract

Abstract: Glucagon-like peptide-1 (GLP-1) is an incretine, which lowers blood glucose dependently on ambient glucose concentration, and its analogues have been used for treatment of type 2 diabetes mellitus. Recent findings including preclinical and clinical studies have demonstrated that GLP-1 and its analogues may have blood-pressure-lowering effect by inhibiting the proximal tubular sodium reabsorption and thereby increasing urinary excretion of sodium, or via an endothelium-independent mechanism.This review summarizes the recent findings regarding the antihypertensive effects of GLP-1 and its analogues.

Key words: Diabetes, Glucagon-like peptide-1, Blood pressure, Mechanism

CLC Number:

CHEN Yong-fei, SHAO Hua, YU Feng. Research progress of glucagon-like peptide-1 and analogues on blood pressure[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(2): 228-233.

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