Abstract: AIM: To compare the level of perioperative serum Interleukin-6(IL-6),tumor necrosis factor-α (TNF-α), high sensitive c-reactive protein (hs-CRP) and blood sugar (BS) between the patients with spinal anesthesia and local anesthesia in peritoneal dialysis catheter placement.METHODS: Forty patients with end stage kidney disease scheduled for peritoneal dialysis catheter placement allocated to one of two groups (n=20 each): group SA received spinal anesthesia, group LA received local anesthesia. The serum IL-6, TNF-α, hs-CRP, BS were measured before operation, at the end of operation and 6 hours after operation, both the visual analogue scale(VAS) while skin incision, open abdominal and at the end of operation and the operation time were recorded.RESULTS: IL-6, TNF-α, hs-CRP were no significant difference between two groups before operation and at the end of operation (P>0.05). Compared with group LA, IL-6, TNF-α, hs-CRP in group SA 6 hours after operation were significantly lower (P<0.05). Compared with before operation, IL-6, TNF-α, hs-CRP in group SA 6 hours after operation were significantly lower (P<0.05). BS at any time were no significant difference between two groups (P>0.05). Compared with group LA,VAS was significantly lower in group SA at any time, operation time was significantly shorter (P<0.01).CONCLUSION: Compared with local anesthesia, peritoneal dialysis catheter placement under spinal anesthesia has advantages of lighter pain, shorter operation time and less inflammatory factor.

Key words: Peritoneal dialysis, Catheter placement, Anesthesia, Spinal, Inflammatory